Format

Send to

Choose Destination
WormBook. 2014 Apr 25:1-47. doi: 10.1895/wormbook.1.77.2.

C. elegans as a model for membrane traffic.

Author information

1
Laboratory of Molecular Traffic, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma 371-8512, Japan. sato-ken@gunma-u.ac.jp; grant@biology.rutgers.edu.

Abstract

The counterbalancing action of the endocytosis and secretory pathways maintains a dynamic equilibrium that regulates the composition of the plasma membrane, allowing it to maintain homeostasis and to change rapidly in response to alterations in the extracellular environment and/or intracellular metabolism. These pathways are intimately integrated with intercellular signaling systems and play critical roles in all cells. Studies in Caenorhabditis elegans have revealed diverse roles of membrane trafficking in physiology and development and have also provided molecular insight into the fundamental mechanisms that direct cargo sorting, vesicle budding, and membrane fisson and fusion. In this review, we summarize progress in understanding membrane trafficking mechanisms derived from work in C. elegans, focusing mainly on work done in non-neuronal cell-types, especially the germline, early embryo, coelomocytes, and intestine.

PMID:
24778088
PMCID:
PMC4096984
DOI:
10.1895/wormbook.1.77.2
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for WormBook Icon for NCBI Bookshelf
Loading ...
Support Center