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Anticancer Res. 2014 May;34(5):2135-44.

Reproducibility of histogram and texture parameters derived from intravoxel incoherent motion diffusion-weighted MRI of FN13762 rat breast Carcinomas.

Author information

1
Department of Radiology, Seoul National University Hospital, 101, Daehangno, Jongno-gu, Seoul 110-744, Korea. cmpark@radiol.snu.ac.kr.

Abstract

AIM:

To determine the reproducibility of histogram and texture parameters derived from intravoxel incoherent motion (IVIM) diffusion-weighted magnetic resonance imaging (MRI) of FN13762 rat breast carcinomas.

MATERIALS AND METHODS:

IVIM diffusion-weighted MRI was performed twice, nine days after tumor implantation in 11 rats. At each session, histogram and texture parameters of entire tumors were extracted from apparent diffusion coefficient (ADC), true-diffusion coefficient (Dt), pseudo-diffusion coefficient (Dp), and perfusion fraction (Pf) maps. Intraobserver and interscan measurement reproducibilities were evaluated using intraclass correlation coefficients (ICC).

RESULTS:

Mean, entropy, 5th, 10th, 25th percentiles from ADC and Dt maps revealed good intra-observer and interscan agreements [lower limits of 95% confidence interval (CI) for ICC≥0.75]. However, all parameters from Dp and Pf maps gave relatively poor intra-observer and interscan agreements (lower limits of 95% CI for ICC<0.75).

CONCLUSION:

Histogram and texture parameters derived from ADC and Dt maps were more reproducible than those from Dp and Pf maps.

KEYWORDS:

FN13762 rat breast carcinoma; Reproducibility; diffusion-weighted MRI; histogram; intravoxel incoherent motion; texture

PMID:
24778015
[Indexed for MEDLINE]

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