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IEEE J Sel Top Quantum Electron. 2014 Mar;20(2):7100108.

Integrated IVUS-OCT Imaging for Atherosclerotic Plaque Characterization.

Author information

1
NIH Ultrasonic Transducer Resource Center and the Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.
2
Department of Biomedical Engineering, the Edwards Life Sciences Center for Advanced Cardiovascular Technology, and Beckman Laser Institute, University of California, Irvine, CA 92697 USA.
3
Department of Biomedical Engineering and Beckman Laser Institute, University of California, Irvine, CA 92697 USA.
4
Division of Cardiology, Irvine Medical Center, University of California, Orange, CA 92868 USA.
5
Beckman Laser Institute, University of California, Irvine, CA 92697 USA.
6
Division of Pulmonary and Critical Care, Irvine Medical Center, University of California, Orange, CA 92868 USA.
7
Edwards Life Sciences Center for Advanced Cardiovascular Technology, University of California, Irvine, CA 92697 USA.

Abstract

For the diagnosis of atherosclerosis, biomedical imaging techniques such as intravascular ultrasound (IVUS) and optical coherence tomography (OCT) have been developed. The combined use of IVUS and OCT is hypothesized to remarkably increase diagnostic accuracy of vulnerable plaques. We have developed an integrated IVUS-OCT imaging apparatus, which includes the integrated catheter, motor drive unit, and imaging system. The dual-function imaging catheter has the same diameter of current clinical standard. The imaging system is capable for simultaneous IVUS and OCT imaging in real time. Ex vivo and in vivo experiments on rabbits with atherosclerosis were conducted to demonstrate the feasibility and superiority of the integrated intravascular imaging modality.

KEYWORDS:

IVUS; OCT; intravascular; multimodal

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