Format

Send to

Choose Destination
Eur Arch Otorhinolaryngol. 2015 Apr;272(4):799-819. doi: 10.1007/s00405-014-3053-z. Epub 2014 Apr 26.

Salivary mucoepidermoid carcinoma revisited.

Author information

1
Department of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain.
2
Instituto Universitario de OncologĂ­a del Principado de Asturias, Oviedo, Spain.
3
Oral Pathology, School of Dentistry, University of Liverpool, Liverpool, UK.
4
Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
5
University of Udine School of Medicine, Piazzale S. Maria della Misericordia, 33100, Udine, Italy.
6
Department of Radiation Oncology, Institute of Oncology, Ljubljana, Slovenia.
7
Division of Oncology, Department of Medicine, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA.
8
Department of Radiation Oncology, University of Florida, Gainesville, FL, USA.
9
Department of Otolaryngology-Head and Neck Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
10
Department of Otorhinolaryngology-Head and Neck Surgery, Leuven Cancer Institute, University Hospitals Leuven - KULeuven, Leuven, Belgium.
11
University of Udine School of Medicine, Piazzale S. Maria della Misericordia, 33100, Udine, Italy. a.ferlito@uniud.it.

Abstract

Clinicopathological features, prognosis and therapeutic strategies for mucoepidermoid carcinoma originating in salivary and salivary-type glands of the head and neck are reviewed. We emphasise histopathological aspects, appraise the value of histochemistry, electron microscopy, immunohistochemistry and cytophotometry, and discuss histogenesis and characteristic gene translocations. We additionally consider possible diagnostic difficulties, problems related to histological grading and accuracy of existing literature, and areas of controversy or uncertainty which may benefit from further investigations.

PMID:
24771140
DOI:
10.1007/s00405-014-3053-z
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center