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FEBS Lett. 2014 May 21;588(10):1973-82. doi: 10.1016/j.febslet.2014.04.020. Epub 2014 Apr 24.

Tumour-suppressive microRNA-224 inhibits cancer cell migration and invasion via targeting oncogenic TPD52 in prostate cancer.

Author information

1
Department of Functional Genomics, Chiba University Graduate School of Medicine, Chiba, Japan; Department of Urology, Chiba University Graduate School of Medicine, Chiba, Japan.
2
Department of Urology, Teikyo University Chiba Medical Centre, Chiba, Japan.
3
Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
4
Department of Functional Genomics, Chiba University Graduate School of Medicine, Chiba, Japan.
5
Department of Urology, Chiba University Graduate School of Medicine, Chiba, Japan.
6
Department of Functional Genomics, Chiba University Graduate School of Medicine, Chiba, Japan. Electronic address: naoseki@faculty.chiba-u.jp.

Abstract

Our recent study of the microRNA expression signature of prostate cancer (PCa) revealed that microRNA-224 (miR-224) is significantly downregulated in PCa tissues. Here, we found that restoration of miR-224 significantly inhibits PCa cell migration and invasion. Additionally, we found that oncogenic TPD52 is a direct target of miR-224 regulation. Silencing of the TPD52 gene significantly inhibits cancer cell migration and invasion. Moreover, TPD52 expression is upregulated in cancer tissues and negatively correlates with miR-224 expression. We conclude that loss of tumour-suppressive miR-224 enhances cancer cell migration and invasion in PCa through direct regulation of oncogenic TPD52.

KEYWORDS:

Prostate cancer; TPD52; Tumour suppressor; miR-224; microRNA

PMID:
24768995
DOI:
10.1016/j.febslet.2014.04.020
[Indexed for MEDLINE]
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