Format

Send to

Choose Destination
Respir Med. 2014 Jun;108(6):931-4. doi: 10.1016/j.rmed.2014.03.009. Epub 2014 Apr 2.

Primary ciliary dyskinesia and humoral immunodeficiency--is there a missing link?

Author information

1
Department of Pediatrics, Pediatric Pulmonology, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium. Electronic address: mieke.boon@uzleuven.be.
2
Department of Pediatrics, Pediatric Pulmonology, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium.
3
Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Gasthuisberg Leuven, Herestraat 49, 3000 Leuven, Belgium.
4
Department of Pediatrics, Pediatric Immunology, University Hospital Gasthuisberg, Herestraat 49, Leuven, Belgium.

Abstract

BACKGROUND:

Primary ciliary dyskinesia (PCD) and humoral mmunodeficiency (HID) are both rare disorders which cause recurrent upper and lower respiratory tract infections.

OBJECTIVE:

To examine the concurrence of PCD and HID in a patient cohort with known PCD.

METHODS:

Retrospective review of the patient files.

RESULTS:

We describe 11 patients of a cohort of 168 patients with PCD (6.5%) with a combination of PCD and some form of HID. The patients all presented with typical clinical symptoms for PCD, however the role of the concomitant immunological abnormalities is not clear.

CONCLUSION:

PCD and HID coincided in 6.5% of the patients. We suggest that a common pathophysiological pathway results in both disorders.

KEYWORDS:

Antibody; Cilia; Humoral immunodeficiency; Primary ciliary dyskinesia

PMID:
24768622
DOI:
10.1016/j.rmed.2014.03.009
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center