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Res Vet Sci. 2014 Oct;97 Suppl:S44-52. doi: 10.1016/j.rvsc.2014.04.002. Epub 2014 Apr 14.

Current ante-mortem techniques for diagnosis of bovine tuberculosis.

Author information

1
MAEVA SERVET SL, C/ de la Fragua 3, 28749, Alameda del Valle, Madrid, Spain; Centro de Vigilancia Sanitaria Veterinaria (VISAVET), Universidad Complutense, Avda. Puerta de Hierro s/n, 28040, Madrid, Spain. Electronic address: jbezosga@gmail.com.
2
Centro de Vigilancia Sanitaria Veterinaria (VISAVET), Universidad Complutense, Avda. Puerta de Hierro s/n, 28040, Madrid, Spain.
3
Prionics AG, Wagistrasse 27A, 8952 Schlieren-Zürich, Switzerland.
4
INGENASA, C/ Hermanos García Noblejas 39, 28037, Madrid, Spain.
5
Centro de Vigilancia Sanitaria Veterinaria (VISAVET), Universidad Complutense, Avda. Puerta de Hierro s/n, 28040, Madrid, Spain; Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, 28040 Madrid, Spain.

Abstract

Bovine tuberculosis (TB), mainly caused by Mycobacterium bovis, is a zoonotic disease with implications for Public Health and having an economic impact due to decreased production and limitations to the trade. Bovine TB is subjected to official eradication campaigns mainly based on a test and slaughter policy using diagnostic assays based on the cell-mediated immune response as the intradermal tuberculin test and the gamma-interferon (IFN-γ) assay. Moreover, several diagnostic assays based on the detection of specific antibodies (Abs) have been developed in the last few years with the aim of complementing the current diagnostic techniques in the near future. This review provides an overview of the current ante-mortem diagnostic tools for diagnosis of bovine TB regarding historical background, methodologies and sensitivity (Se) and specificity (Sp) obtained in previous studies under different epidemiological situations.

KEYWORDS:

Cattle; Gamma-interferon assay; Serology; Tuberculin test; Tuberculosis

PMID:
24768355
DOI:
10.1016/j.rvsc.2014.04.002
[Indexed for MEDLINE]

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