Format

Send to

Choose Destination
See comment in PubMed Commons below
Mol Cell. 2014 Apr 24;54(2):289-96. doi: 10.1016/j.molcel.2014.03.040.

The cGAS-cGAMP-STING pathway of cytosolic DNA sensing and signaling.

Author information

1
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
2
Beth Israel Deaconess Medical Center, Boston, MA 02115, USA. Electronic address: ychiu@bidmc.harvard.edu.
3
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: zhijian.chen@utsouthwestern.edu.

Abstract

The innate immune system deploys a variety of sensors to detect signs of infection. Nucleic acids represent a major class of pathogen signatures that can trigger robust immune responses. The presence of DNA in the cytoplasm of mammalian cells is a danger signal that activates innate immune responses; however, how cytosolic DNA triggers these responses remained unclear until recently. In this review, we focus on the mechanism of DNA sensing by the newly discovered cGAS-cGAMP-STING pathway and highlight recent progress in dissecting the in vivo functions of this pathway in immune defense as well as autoimmunity.

PMID:
24766893
DOI:
10.1016/j.molcel.2014.03.040
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center