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Cancer Invest. 2014 Jul;32(6):248-55. doi: 10.3109/07357907.2014.907420. Epub 2014 Apr 25.

External beam radiotherapy ± chemotherapy in the treatment of anal canal cancer: a single-institute long-term experience on 100 patients.

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1
1Department of Radiation Oncology, Istituto del Radio, Spedali Civili di Brescia - University of Brescia , Brescia , Italy.

Abstract

One-hundred patients treated with curative radiotherapy (RT) ± chemotherapy (CT) for an anal canal carcinoma (T1-4N0-3M0) were retrospectively analyzed. Five- and 10-year local control (LC) rates were 73% and 67%, respectively. Acute and late G3-G4 toxicity rates were 32% and 12%, respectively. Two patients underwent a colostomy for a G4 anal toxicity. This study confirms the outcomes of RT ± CT in the treatment of anal canal cancer. Concomitant CT and LC statistically influenced Overall Survival and Colostomy-Free Survival. CT also statistically reduced the risk of nodal relapse. High rates of acute skin toxicity impose tailored volumes and techniques of irradiation.

KEYWORDS:

Anal cancer; Chemotherapy; Local control; Radiochemotherapy; Radiotherapy; Toxicity

PMID:
24766302
DOI:
10.3109/07357907.2014.907420
[Indexed for MEDLINE]
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