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Turk J Haematol. 2014 Mar;31(1):75-8. doi: 10.4274/Tjh.2012.0028. Epub 2014 Mar 5.

Central nervous system involvement of T-cell prolymphocytic leukemia diagnosed with stereotactic brain biopsy: case report.

Author information

1
Gülhane Military Medical Academy, Haydarpaşa Training Hospital, Department of Neurosurgery, İstanbul, Turkey.
2
Gülhane Military Medical Academy, Department of Neurosurgery, Ankara, Turkey.
3
Gülhane Military Medical Academy, Haydarpaşa Training Hospital, Department of Hematology, İstanbul, Turkey.
4
Gülhane Military Medical Academy, Haydarpaşa Training Hospital, Department of Pathology, İstanbul, Turkey.

Abstract

in English, Turkish

Prolymphocytic leukemia (PLL) is a generalized malignancy of the lymphoid tissue characterized by the accumulation of monoclonal lymphocytes, usually of B cell type. Involvement of the central nervous system (CNS) is an extremely rare complication of T-cell prolymphocytic leukemia (T-PLL). We describe a case of T-PLL presenting with symptomatic infiltration of the brain that was histopathologically proven by stereotactic brain biopsy. We emphasize the importance of rapid diagnosis and immediate treatment for patients presenting with CNS involvement and a history of leukemia or lymphoma.

KEYWORDS:

Central nervous system; Cerebral involvement; Stereotactic biopsy; T-cell prolymphocytic leukemia

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