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World J Gastroenterol. 2014 Apr 21;20(15):4128-40. doi: 10.3748/wjg.v20.i15.4128.

Role of the tissue microenvironment as a therapeutic target in hepatocellular carcinoma.

Author information

1
Bhavna Rani, Yuan Cao, Gianluigi Giannelli, Department of Medical Biosciences and Human Oncology, Padiglione Semeiotica Medica, 70124 Bari, Italy.

Abstract

Hepatocellular carcinoma is difficult to treat, primarily because the underlying molecular mechanisms driving clinical outcome are still poorly understood. Growing evidence suggests that the tissue microenvironment has a role in the biological behavior of the tumor. The main clinical issue is to identify the best target for therapeutic approaches. Here, we discuss the hypothesis that the entire tissue microenvironment might be considered as a biological target. However, the tissue microenvironment consists of several cellular and biochemical components, each of which displays a distinct biological activity. We discuss the major components of this environment and consider how they may interact to promote tumor/host crosstalk.

KEYWORDS:

Cancer stem cells; Hepatocellular carcinoma; Laminin-5; Target therapy; Therapy; Tissue microenvironment; Transforming growth factor-beta

PMID:
24764651
PMCID:
PMC3989949
DOI:
10.3748/wjg.v20.i15.4128
[Indexed for MEDLINE]
Free PMC Article

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