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Science. 2014 Apr 25;344(6182):380-6. doi: 10.1126/science.1249656.

Genome sequence of the tsetse fly (Glossina morsitans): vector of African trypanosomiasis.

Collaborators (179)

Watanabe J, Hattori M, Berriman M, Lehane MJ, Hall N, Solano P, Aksoy S, Hide W, Touré Y, Attardo GM, Darby AC, Toyoda A, Hertz-Fowler C, Larkin DM, Cotton JA, Watanabe J, Sanders MJ, Swain MT, Hattori M, Berriman M, Quail MA, Inoue N, Ravel S, Taylor TD, Srivastava TP, Sharma V, Warren W, Wilson RK, Suzuki Y, Lawson D, Hughes DS, Megy K, Masiga DK, Mireji PO, Attardo GM, Hansen IA, Van Den Abbeele J, Benoit JB, Bourtzis K, Lehane MJ, Aksoy S, Masiga DK, Obiero GF, Robertson HM, Jones JW, Zhou JJ, Field LM, Friedrich M, Mireji PO, Nyanjom SR, Telleria EL, Caljon G, Van Den Abbeele J, Ribeiro JM, Acosta-Serrano A, Benoit JB, Ooi CP, Rose C, Price DP, Haines LR, Lehane MJ, Christoffels A, Sim C, Pham DQ, Denlinger DL, Geiser L, Omedo IA, Benoit JB, Winzerling JJ, Peyton JT, Marucha KK, Jonas M, Meuti ME, Rawlings ND, Mireji PO, Zhang Q, Macharia RW, Michalkova V, Dashti ZJ, Baumann AA, Gäde G, Marco HG, Hansen IA, Caers J, Schoofs L, Riehle MA, Hu W, Tu Z, Tarone AM, Malacrida AR, Kibet CK, Benoit JB, Scolari F, Attardo GM, Koekemoer JJ, Willis J, Gomulski LM, Falchetto M, Scott MJ, Fu S, Sze SH, Luiz T, Weiss B, Walshe DP, Wang J, Benoit JB, Attardo GM, Wamalwa M, Mwangi S, Aksoy S, Ramphul UN, Snyder AK, Brelsfoard CL, Thomas GH, Tsiamis G, Bourtzis K, Arensburger P, Rio RV, Macdonald SJ, Panji S, Kruger A, Christoffels A, Benkahla A, Balyeidhusa AS, Msangi A, Ooi CP, Okoro CK, Masiga DK, Stephens D, Walshe DP, Stanley EJ, Mpondo F, Wamwiri F, Mramba F, Attardo GM, Siwo G, Obiero GF, Githinji G, Harkins G, Murilla G, Lehväslaiho H, Malele I, Koekemoer JJ, Auma JE, Kinyua JK, Ouma J, Watanabe J, Megy K, Okedi L, Manga L, Jonas M, Wamalwa M, Aslett M, Koffi M, Berriman M, Lehane MJ, Gaunt MW, Makgamathe M, Hall N, Mulder N, Manangwa O, Abila PP, Wincker P, Mireji PO, Gregory R, Rio RV, Bateta R, Sakate R, Aksoy S, Ommeh S, Lehane S, Nyanjom SR, Imanishi T, Taylor TD, Osamor VC, Sharma V, Hide W, Kawahara Y, Benoit JB.

Abstract

Tsetse flies are the sole vectors of human African trypanosomiasis throughout sub-Saharan Africa. Both sexes of adult tsetse feed exclusively on blood and contribute to disease transmission. Notable differences between tsetse and other disease vectors include obligate microbial symbioses, viviparous reproduction, and lactation. Here, we describe the sequence and annotation of the 366-megabase Glossina morsitans morsitans genome. Analysis of the genome and the 12,308 predicted protein-encoding genes led to multiple discoveries, including chromosomal integrations of bacterial (Wolbachia) genome sequences, a family of lactation-specific proteins, reduced complement of host pathogen recognition proteins, and reduced olfaction/chemosensory associated genes. These genome data provide a foundation for research into trypanosomiasis prevention and yield important insights with broad implications for multiple aspects of tsetse biology.

PMID:
24763584
PMCID:
PMC4077534
DOI:
10.1126/science.1249656
[Indexed for MEDLINE]
Free PMC Article

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