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J Cancer Res Ther. 2014 Jan-Mar;10(1):103-6. doi: 10.4103/0973-1482.131407.

Immunohistochemical expression of syndecan-1 in oral dysplastic epithelium.

Author information

1
Department of Oral Pathology, Al-Ameen Dental College, Bijapur, India.

Abstract

BACKGROUND:

In stratified squamous epithelia, syndecan-1 is proposed to function as a cellto cell adhesion molecule, and plays an important role in regulation of cell growth and differentiation during the developmental process. Oral cancer is a disease with complex etiology, so biological behavior in carcinomas preceded by dysplastic states is difficult to assess and predict its prognosis. Hence, syndecan-1, a recently recognized tumor marker has been proved to be an eminent diagnostic and prognostic tool in assessing biological behavior of various potentially premalignant andmalignant lesions.

MATERIALS AND METHODS:

The study group consisted of 40 specimens of premalignant stateand 10 specimens of normal mucosa.Thesections were stained withhematoxylin and eosin, andimmunohistochemicallyusing syndecan-1 a primary antibody and was observed under light microscope.

RESULTS:

Expression decreased with the decreasing grades of dysplasia.

CONCLUSION:

Syndecan-1 can be efficiently used in early detection and diagnosis of oral carcinoma.

PMID:
24762495
DOI:
10.4103/0973-1482.131407
[Indexed for MEDLINE]
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