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Clin Infect Dis. 2014 Aug 15;59(4):596-600. doi: 10.1093/cid/ciu284. Epub 2014 Apr 23.

Dependence on the CCR5 coreceptor for viral replication explains the lack of rebound of CXCR4-predicted HIV variants in the Berlin patient.

Author information

1
Department of Medical Microbiology and Virology, University Medical Center, Utrecht, The Netherlands.
2
Department of Internal Medicine, Infectious Diseases and Psychosomatic Medicine, Ghent University Hospital, Belgium.
3
Institute of Transfusion Medicine and Immunology, Heidelberg, Germany.
4
Department of Medicine, University of California, San Francisco.

Abstract

The "Berlin patient" is the first patient cured of HIV-1 infection after allogeneic transplantation with nonfunctional CCR5 coreceptor stem cells. We demonstrate that CXCR4-predicted minority viruses present prior to transplantation were unable to rebound after transplantation due to their dependence on CCR5 for replication and high genetic barrier toward CXCR4 usage.

KEYWORDS:

Berlin-Patient; HIV; coreceptor; cure; stem cell transplantation

PMID:
24759824
PMCID:
PMC4990826
DOI:
10.1093/cid/ciu284
[Indexed for MEDLINE]
Free PMC Article
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