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Biochem Biophys Res Commun. 2014 May 16;447(4):644-8. doi: 10.1016/j.bbrc.2014.04.056. Epub 2014 Apr 20.

Panax red ginseng extract regulates energy expenditures by modulating PKA dependent lipid mobilization in adipose tissue.

Author information

1
Department of Biomedical Sciences, Cell Dysfunction Research Center (CDRC), University of Ulsan, College of Medicine, Seoul 138-736, Republic of Korea.
2
Department of Anatomy and Cell Biology, University of Ulsan, College of Medicine, Seoul 138-736, Republic of Korea.
3
Department of Biomedical Sciences, Cell Dysfunction Research Center (CDRC), University of Ulsan, College of Medicine, Seoul 138-736, Republic of Korea; Department of Anatomy and Cell Biology, University of Ulsan, College of Medicine, Seoul 138-736, Republic of Korea.
4
Department of Biomedical Sciences, Cell Dysfunction Research Center (CDRC), University of Ulsan, College of Medicine, Seoul 138-736, Republic of Korea; Department of Anatomy and Cell Biology, University of Ulsan, College of Medicine, Seoul 138-736, Republic of Korea. Electronic address: ysong@amc.seoul.kr.

Abstract

Regulation of balance between lipid accumulation and energy consumption is a critical step for the maintenance of energy homeostasis. Here, we show that Panax red ginseng extract treatments increased energy expenditures and prevented mice from diet induced obesity. Panax red ginseng extracts strongly activated Hormone Specific Lipase (HSL) via Protein Kinase A (PKA). Since activation of HSL induces lipolysis in WAT and fatty acid oxidation in brown adipose tissue (BAT), these results suggest that Panax red ginseng extracts reduce HFD induced obesity by regulating lipid mobilization.

KEYWORDS:

Adipose tissue; Energy expenditures; Obesity; Panax ginseng; Protein Kinase A

PMID:
24759232
DOI:
10.1016/j.bbrc.2014.04.056
[Indexed for MEDLINE]
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