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Neuropsychopharmacology. 2015 Jan;40(1):190-206. doi: 10.1038/npp.2014.95. Epub 2014 Apr 24.

Neurodevelopment, GABA system dysfunction, and schizophrenia.

Author information

1
Department of Psychiatry, Vanderbilt University, Nashville, TN, USA.
2
1] Department of Psychiatry, Vanderbilt University, Nashville, TN, USA [2] Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, TN, USA [3] Department of Psychiatry, University of Szeged, Szeged, Hungary.

Abstract

The origins of schizophrenia have eluded clinicians and researchers since Kraepelin and Bleuler began documenting their findings. However, large clinical research efforts in recent decades have identified numerous genetic and environmental risk factors for schizophrenia. The combined data strongly support the neurodevelopmental hypothesis of schizophrenia and underscore the importance of the common converging effects of diverse insults. In this review, we discuss the evidence that genetic and environmental risk factors that predispose to schizophrenia disrupt the development and normal functioning of the GABAergic system.

PMID:
24759129
PMCID:
PMC4262918
DOI:
10.1038/npp.2014.95
[Indexed for MEDLINE]
Free PMC Article

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