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Eur J Med Res. 2014 Apr 23;19:21. doi: 10.1186/2047-783X-19-21.

The correlation between the expression of differentiated embryo-chondrocyte expressed gene l and oral squamous cell carcinoma.

Author information

1
Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Central-South University, Changsha 410008, China. tongsus@163.com.

Abstract

BACKGROUND:

This study aims to explore the correlation between expression of differentiated embryo-chondrocyte expressed gene l (DEC1) and oral squamous cell carcinoma (OSCC), which could provide the reference for treatment and prognosis assessment of OSCC.

METHODS:

The expression of DEC1 in tissues from 56 primary OSCC patients and 20 normal oral mucosa samples were detected using real-time polymerase chain reaction and immunohistochemical methods, respectively.

RESULTS:

The results showed that the positive expression rate of DEC1 in the OSCC group was significantly higher than that in the normal group (P <0.05); further, the expression of DEC1 in different OSCC groups was statistically significant (P <0.05). The expression of DEC1 in the 1-year recurrence OSCC group was significantly higher than other groups. The expression of DEC1 in the 3-years no recurrence OSCC group was the lowest.

CONCLUSIONS:

The expression of DEC1 was associated with the incidence of OSCC and there was a negative correlation between the expression of DEC1 and the prognosis of OSCC.

PMID:
24758579
PMCID:
PMC4011512
DOI:
10.1186/2047-783X-19-21
[Indexed for MEDLINE]
Free PMC Article

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