Format

Send to

Choose Destination
J Neuroeng Rehabil. 2014 Apr 23;11:73. doi: 10.1186/1743-0003-11-73.

Biomechanical and functional variation in rat sciatic nerve following cuff electrode implantation.

Author information

1
Fischell Department of Bioengineering, University of Maryland, College Park, MD, USA. sbshah@ucsd.edu.

Abstract

BACKGROUND:

Nerve cuff electrodes are commonly and successfully used for stimulating peripheral nerves. On the other hand, they occasionally induce functional and morphological changes following chronic implantation, for reasons not always clear. We hypothesize that restriction of nerve mobility due to cuff implantation may alter nerve conduction.

METHODS:

We quantified acute changes in nerve-muscle electrophysiology, using electromyography, and nerve kinematics in anesthetized Sprague Dawley rat sciatic nerves during controlled hindlimb joint movement. We compared electrophysiological and biomechanical response in uncuffed nerves and those secured within a cuff electrode using analysis of variance (ANOVA) and regression analysis.

RESULTS:

Tethering resulting from cuff implantation resulted in altered nerve strain and a complex biomechanical environment during joint movement. Coincident with biomechanical changes, electromyography revealed significantly increased variability in the response of conduction latency and amplitude in cuffed, but not free, nerves following joint movement.

CONCLUSION:

Our findings emphasize the importance of the mechanical interface between peripheral nerves and their devices on neurophysiological performance. This work has implications for nerve device design, implantation, and prediction of long-term efficacy.

PMID:
24758405
PMCID:
PMC4022540
DOI:
10.1186/1743-0003-11-73
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center