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Mult Scler. 2014 Nov;20(13):1699-703. doi: 10.1177/1352458514531086. Epub 2014 Apr 22.

Lack of confirmation of anti-inward rectifying potassium channel 4.1 antibodies as reliable markers of multiple sclerosis.

Author information

1
Gui-de-Chauliac Hospital, France.
2
The Neuroscience Institute of Montpellier, Inserm UMR1051, Saint Eloi Hospital, France.
3
CHU Nimes, France.
4
Saint Eloi Hospital, France.
5
The Neuroscience Institute of Montpellier, Inserm UMR1051, Saint Eloi Hospital, France/Saint Eloi Hospital, France t-vincent@chu-montpellier.fr.

Abstract

BACKGROUND:

auto-antibodies against the potassium channel inward rectifying potassium channel 4.1 (Kir4.1) have previously been identified in 46% of patients with multiple sclerosis (MS).

OBJECTIVES:

to confirm these findings.

METHODS:

we evaluated the presence of anti-Kir4.1 antibodies by enzyme-linked immunosorbent assay (ELISA) and immunofluorescence in 268 MS patients, 46 patients with other neurological diseases (OND) and 45 healthy controls.

RESULTS:

anti-Kir4.1 antibodies were found in 7.5% of MS patients, 4.3% of OND patients and 4.4% of healthy controls. Immunofluorescence analysis did not identify any specific staining.

CONCLUSIONS:

we confirmed the presence of anti-Kir4.1 antibodies in MS patients, but at a much lower prevalence than previously reported.

KEYWORDS:

ELISA; Kir4.1 antibody; Multiple sclerosis; biomarker; diagnosis

PMID:
24756568
DOI:
10.1177/1352458514531086
[Indexed for MEDLINE]

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