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Cancer Epidemiol Biomarkers Prev. 2014 Jul;23(7):1273-9. doi: 10.1158/1055-9965.EPI-13-1218. Epub 2014 Apr 22.

Risk of breast cancer recurrence associated with carbohydrate intake and tissue expression of IGFI receptor.

Author information

1
Authors' Affiliations: Cancer Prevention and Control Program, Moores UCSD Cancer Center, Department of Family and Preventive Medicine; and.
2
Department of Pathology, University of California, San Diego, La Jolla, California.
3
Authors' Affiliations: Cancer Prevention and Control Program, Moores UCSD Cancer Center, Department of Family and Preventive Medicine; and repatterson@ucsd.edu.

Abstract

BACKGROUND:

The insulin-like growth factor-I (IGFI) receptor is a potential target for breast cancer treatment and may be influenced by dietary intake.

METHODS:

Nested, case-control study of 265 postmenopausal breast cancer survivors; primary breast cancer tissue was stained to determine IGFI receptor status. Change in carbohydrate intake from baseline to year 1 of study was estimated from 24-hour dietary recalls. Breast cancer recurrence cases (91) were matched to two controls (n = 174) on disease and study characteristics and counter matched on change in carbohydrate intake. Weighted conditional logistic regression models fit the risk of recurrence on IGFI receptor status and dietary change.

RESULTS:

Half of the tumors were IGFI receptor positive. Increased risk of recurrence was associated with IGFI receptor-positive status [HR 1.7; 95% confidence interval (CI), 1.2-2.5] and, separately, with a stable/increased intake of carbohydrates (HR 2.0; 95% CI, 1.3-5.0). There was a borderline significant interaction between those two variables (P = 0.11). Specifically, carbohydrate intake had no significant impact on risk of recurrence among women who were receptor negative, yet increased the risk of recurrence by more than 5-fold among women who were receptor positive (HR 5.5; 95% CI, 1.8-16.3).

CONCLUSIONS:

Among women whose tumor tissue is positive for the IGFI receptor, reducing carbohydrate intake after diagnosis could reduce the risk of breast cancer recurrence. These findings need replication in a larger sample.

IMPACT:

This is the first study to suggest that it may be possible to personalize dietary recommendations for breast cancer survivors based on molecular characteristics of their primary tumor tissue. .

PMID:
24755714
PMCID:
PMC4082443
DOI:
10.1158/1055-9965.EPI-13-1218
[Indexed for MEDLINE]
Free PMC Article

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