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BMB Rep. 2014 Apr;47(4):192-6.

The diverse roles of RNA polymerase II C-terminal domain phosphatase SCP1.

Author information

1
Departments of Applied Biochemistry Research Center, Konkuk University, Chungju 380-701, Korea.
2
Departments of Nanotechnology Research Center, Konkuk University, Chungju 380-701, Korea.
3
Departments of Applied Biochemistry and Nanotechnology Research Center, Konkuk University, Chungju 380-701, Korea.

Abstract

RNA polymerase II carboxyl-terminal domain (pol II CTD) phosphatases are a newly emerging family of phosphatases that are members of DXDX (T/V). The subfamily includes Small CTD phosphatases, like SCP1, SCP2, SCP3, TIMM50, HSPC129 and UBLCP. Extensive study of SCP1 has elicited the diversified roles of the small C terminal domain phosphatase. The SCP1 plays a vital role in various biological activities, like neuronal gene silencing and preferential Ser5 dephosphorylation, acts as a cardiac hypertrophy inducer with the help of its intronic miRNAs, and has shown a key role in cell cycle regulation. This short review offers an explanation of the mechanism of action of small CTD phosphatases, in different biological activities and metabolic processes.

PMID:
24755554
PMCID:
PMC4163886
DOI:
10.5483/bmbrep.2014.47.4.060
[Indexed for MEDLINE]
Free PMC Article

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