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DNA Repair (Amst). 2014 Jul;19:163-8. doi: 10.1016/j.dnarep.2014.03.015. Epub 2014 Apr 19.

Double strand break (DSB) repair in heterochromatin and heterochromatin proteins in DSB repair.

Author information

1
Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), UMR 7104 CNRS, UdS, INSERM U964, BP 10142, F-67404 Illkirch Cedex, CU de Strasbourg, France.
2
Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), UMR 7104 CNRS, UdS, INSERM U964, BP 10142, F-67404 Illkirch Cedex, CU de Strasbourg, France. Electronic address: evisou@igbmc.fr.

Abstract

Chromosomal translocations are a hallmark of cancer cells and they represent a major cause of tumorigenesis. To avoid chromosomal translocations, faithful repair of DNA double strand breaks (DSBs) has to be ensured in the context of high ordered chromatin structure. However, chromatin compaction is proposed to represent a barrier for DSB repair. Here we review the different mechanisms cells use to alleviate the heterochromatic barrier for DNA repair. At the same time, we discuss the activating role of heterochromatin-associated proteins in this process, therefore proposing that chromatin structure, more than being a simple barrier, is a key modulator of DNA repair.

KEYWORDS:

DDR; DNA repair; DSB; HP1; Heterochromatin; KAP1

PMID:
24754998
DOI:
10.1016/j.dnarep.2014.03.015
[Indexed for MEDLINE]

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