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Future Oncol. 2014 Mar;10(4):647-54. doi: 10.2217/fon.13.228.

Use of artemisinin and its derivatives to treat HPV-infected/transformed cells and cervical cancer: a review.

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Division of Gynecologic Oncology, Cleveland Clinic, Cleveland, OH 44195, USA.


Cervical cancer and HPV-related diseases remain a burden in the developing world. While much progress has been gained in the detection of HPV and preneoplastic cervical lesions, the rate-limiting step in the prevention of cervical cancer is management of these women. A natural compound, artemisinin, and its derivatives appear to hold promise as a simple means of treatment. Laboratory studies have shown that this compound, and its derivatives, have activity against HPV-infected and -transformed cells and cervical cancer cells. In situations of compassionate use, studies have also demonstrated efficacy in clinical situations. Well-designed clinical trials relating to its use should be undertaken.

[Indexed for MEDLINE]

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