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Trop Parasitol. 2014 Jan;4(1):4-9. doi: 10.4103/2229-5070.129142.

Drug resistance in leishmaniasis: Newer developments.

Author information

1
Department of Microbiology, Vardhaman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.

Abstract

Leishmaniasis is a vector borne protozoan disease and it remains a major public health problem world-wide. Lack of an effective vaccine and vector control program makes the chemotherapy as the primary tool for leishmaniasis. Antimonials were used as the first line of treatment for many years. Emergence of resistance against this drug has become a major concern. Literatures and studies published on anti-leishmanial drug resistance, newer drug discovery for leishmanial resistance etc., in PubMed, Medline and Google search and reviewed thoroughly. Various newer drugs have been identified but, are in limited use because of high cost, toxicity, resistance etc., Recently, many newer mechanisms of drug resistance have been identified which may boost in future designing and development of drugs.

KEYWORDS:

Amphotericin B; antimonials; drug resistance; leishmaniasis; miltefocine; paromomycin

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