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Biomicrofluidics. 2014 Feb 3;8(1):016502. doi: 10.1063/1.4863576. eCollection 2014 Jan.

Coaxial flow focusing in poly(dimethylsiloxane) microfluidic devices.

Author information

1
Joint UCSF/UCB Bioengineering Graduate Group, University of California, San Francisco 1700, 4th Street, Byers Hall 303C, San Francisco, California 94158, USA.
2
Department of Bioengineering and Therapeutic Sciences, California Institute for Quantitative Biosciences (QB3), University of California, San Francisco 1700, 4th Street, Byers Hall 303C, San Francisco, California 94158, USA.

Abstract

We have developed a coaxial flow focusing geometry that can be fabricated using soft lithography in poly(dimethylsiloxane) (PDMS). Like coaxial flow focusing in glass capillary microfluidics, our geometry can form double emulsions in channels with uniform wettability and of a size much smaller than the channel dimensions. However, In contrast to glass capillary coaxial flow focusing, our geometry can be fabricated using lithographic techniques, allowing it to be integrated as the drop making unit in parallel drop maker arrays. Our geometry enables scalable formation of emulsions down 7 μm in diameter, in large channels that are robust against fouling and clogging.

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