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EMBO J. 1989 May;8(5):1403-10.

A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas.

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Department of Genetics, Harvard Medical School, Boston, MA.


B cells and primary carcinomas express a surface molecule, Bp50 (CDw40), absent from other hematopoietic cells and from normal epithelium, and thought to play a regulatory role in B-cell maturation and epithelial neoplasia. In this work the sequence of a cDNA clone encoding Bp50 was analyzed by a newly derived transition matrix method. Among several interesting relationships with known receptors was found an extensive homology with the nerve growth factor receptor. The mRNA is induced by gamma-interferon in both B cells and epithelial neoplasms, suggesting a role for the molecule in the development of carcinomas at sites of chronic inflammation.

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