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Luminescence. 2014 Dec;29(8):1053-8. doi: 10.1002/bio.2659. Epub 2014 Apr 22.

Potassium permanganate-acridine yellow chemiluminescence system for the determination of fluvoxamine, isoniazid and ceftriaxone.

Author information

1
Department of Chemistry, East Azerbaijan Science and Research Branch, Islamic Azad University, Tabriz, Iran.

Abstract

Based on the oxidation of acridine yellow by permanganate in basic medium, a new chemiluminescence system was developed for the sensitive determination of some important drugs. The remarkable inhibiting effect of fluvoxamine, ceftriaxone and isoniazid on this reaction was applied to their detection. A possible mechanism was proposed for this system based on chemiluminescence emission wavelengths and experimental observations. Under optimum conditions, calibration graphs were obtained for 1 × 10(-9) to 1 × 10(-6) mol/L of fluvoxamine; 2 × 10(-8) to 8 × 10(-6) mol/L of ceftriaxone and 5 × 10(-8) to 4 × 10(-5) mol/L of isoniazid. This proposed method was satisfactorily used in the determination of these drugs in pharmaceutical samples and human urine and serum.

KEYWORDS:

acridine yellow; chemiluminescence; drug; permanganate

PMID:
24753178
DOI:
10.1002/bio.2659
[Indexed for MEDLINE]
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