Lycojaponicuminol A-F: cytotoxic serratene triterpenoids from Lycopodium japonicum

Fitoterapia. 2014 Jul:96:95-102. doi: 10.1016/j.fitote.2014.04.012. Epub 2014 Apr 18.

Abstract

Six new serratene triterpenoids (1-6), together with nine known triterpenoid compounds were isolated from the extract of club moss Lycopodium japonicum. The structures of isolated compounds were established by spectroscopic methods. The cytotoxic activities of all compounds were evaluated against three human cancer cell lines in vitro by MTT assay. Compounds 2, 6-8 and 11 exhibited moderate activities against all three cell lines with IC50 values of 2.28-11.81 μg/mL.

Keywords: Cytotoxic; Lycopodiaceae; Lycopodium japonicum; Serratene triterpenoid.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Cell Survival / drug effects
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / isolation & purification
  • Drugs, Chinese Herbal / pharmacology*
  • Humans
  • Inhibitory Concentration 50
  • Lycopodium / chemistry*
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Triterpenes / chemistry
  • Triterpenes / isolation & purification
  • Triterpenes / pharmacology*

Substances

  • Antineoplastic Agents, Phytogenic
  • Drugs, Chinese Herbal
  • Triterpenes