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Trends Endocrinol Metab. 2014 Aug;25(8):415-24. doi: 10.1016/j.tem.2014.03.008. Epub 2014 Apr 18.

Zinc transporter 8 (ZnT8) and β cell function.

Author information

1
Barbara Davis Center for Diabetes, University of Colorado Denver Anschutz Medical Campus, Aurora, CO 80045, USA; Integrated Department of Immunology, University of Colorado Denver Anschutz Medical Campus, Aurora, CO 80045, USA. Electronic address: howard.davidson@ucdenver.edu.
2
Barbara Davis Center for Diabetes, University of Colorado Denver Anschutz Medical Campus, Aurora, CO 80045, USA.
3
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. Electronic address: richard.obrien@vanderbilt.edu.

Abstract

Human pancreatic β cells have exceptionally high zinc content. In β cells the highest zinc concentration is in insulin secretory granules, from which it is cosecreted with the hormone. Uptake of zinc into secretory granules is mainly mediated by zinc transporter 8 (ZnT8), the product of the SLC30A8 [solute carrier family 30 (zinc transporter), member 8] gene. The minor alleles of several single-nucleotide polymorphisms (SNPs) in SLC30A8 are associated with decreased risk of type 2 diabetes (T2D), but the precise mechanisms underlying the protective effects remain uncertain. In this article we review current knowledge of the role of ZnT8 in maintaining zinc homeostasis in β cells, its role in glucose metabolism based on knockout mouse studies, and current theories regarding the link between ZnT8 function and T2D.

KEYWORDS:

SLC30A8; Slc30a8; islet

PMID:
24751356
PMCID:
PMC4112161
DOI:
10.1016/j.tem.2014.03.008
[Indexed for MEDLINE]
Free PMC Article

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