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Carbohydr Polym. 2014 Aug 8;108:17-25. doi: 10.1016/j.carbpol.2014.01.105. Epub 2014 Mar 12.

Polysaccharides isolated from Digenea simplex inhibit inflammatory and nociceptive responses.

Author information

1
Laboratory of Proteins and Carbohydrates of Marine Algae, Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, Brazil.
2
LAFICA - Laboratory of Pharmacology of Inflammation and Cancer, Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil.
3
LAFFEX - Laboratory of Experimental Physiopharmacology, Biotechnology and Biodiversity Center Research (BIOTEC), Federal University of Piauí, Parnaiba, Piauí, Brazil.
4
Polymer Laboratory, Department of Organic and Inorganic Chemistry, Federal University of Ceará, Fortaleza, Brazil.
5
LAFFEX - Laboratory of Experimental Physiopharmacology, Biotechnology and Biodiversity Center Research (BIOTEC), Federal University of Piauí, Parnaiba, Piauí, Brazil. Electronic address: andreluiz@ufpi.edu.br.
6
Laboratory of Proteins and Carbohydrates of Marine Algae, Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, Brazil. Electronic address: pfreitas@ufc.br.

Abstract

Polysaccharides (PLS) have notably diverse pharmacological properties. In the present study, we investigated the previously unexplored anti-inflammatory and antinociceptive activities of the PLS fraction isolated from the marine red alga Digenea simplex. We found that the PLS fraction reduced carrageenan-induced edema in a dose-dependent manner, and inhibited inflammation induced by dextran, histamine, serotonin, and bradykinin. The fraction also inhibited neutrophil migration into both mouse paw and peritoneal cavity. This effect was accompanied by decreases in IL1-β and TNF-α levels in the peritoneal fluid. Pre-treatment of mice with PLS (60 mg/kg) significantly reduced acetic acid-induced abdominal writhing. This same dose of PLS also reduced total licking time in both phases of a formalin test, and increased latency in a hot plate test. Therefore, we conclude that PLS extracted from D. simplex possess anti-inflammatory and antinociceptive activities and can be useful as therapeutic agents against inflammatory diseases.

KEYWORDS:

Anti-inflammatory; Antinociceptive; Polysaccharides

PMID:
24751242
DOI:
10.1016/j.carbpol.2014.01.105
[Indexed for MEDLINE]

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