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Eur J Neurol. 2015 Jan;22(1):215-8. doi: 10.1111/ene.12421. Epub 2014 Apr 22.

Cerebrospinal fluid neurofilament light chain levels: marker of progression to generalized amyotrophic lateral sclerosis.

Author information

1
Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari, Bari, Italy; Department of Clinical Research in Neurology, Unit of Neurodegenerative Diseases, University of Bari, c/o Pia Fondazione Card. G. Panico, Tricase (Lecce), Italy.

Abstract

BACKGROUND AND PURPOSE:

To evaluate whether cerebrospinal fluid (CSF) neurofilament light chain (NFL) levels could predict the time to generalization (TTG) in amyotrophic lateral sclerosis (ALS).

METHODS:

Cerebrospinal fluid NFL levels of 37 cases of sporadic ALS were measured and the time of symptom spreading from spinal or bulbar localization to both (TTG) was evaluated in all patients.

RESULTS:

Kaplan-Meier analysis showed a short TTG in patients with high NFL levels (log-rank test chi-squared = 19.4, P < 0.0001). In a multivariate regression model patients with NFL levels above the median had an eight-fold higher risk of generalization (adjusted hazard ratio 7.9, 95% confidence interval 2.9-21.4, P < 0.0001) compared with those with NFL levels below the median.

CONCLUSIONS:

This study shows that in sporadic ALS NFL, a marker of neurodegeneration, is correlated with TTG, a clinical intermediate parameter of survivorship.

KEYWORDS:

ALS; CSF; biomarkers

PMID:
24750431
DOI:
10.1111/ene.12421
[Indexed for MEDLINE]

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