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Acta Ophthalmol (Copenh). 1989 Jun;67(3):333-8.

Conjunctival keratinisation, an abnormal reaction to an ocular beta-blocker.

Author information

1
Department of Ophthalmology, University Hospital, Leiden, The Netherlands.

Abstract

Conjunctival leucoplakia was induced by the local beta-blocker metipranolol in one case. Withdrawal of the drug and application of all-trans retinoic acid ointment resulted in resolving of the keratinisation. A striking pharmacological resemblance is discovered between metipranolol and practolol. Metipranolol seems to be a less toxic phenol derivative of practolol. Nevertheless, it seems able to act as antigen.

PMID:
2475010
[Indexed for MEDLINE]

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