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Molecules. 2014 Apr 17;19(4):4924-40. doi: 10.3390/molecules19044924.

The synergistic biologic activity of oleanolic and ursolic acids in complex with hydroxypropyl-γ-cyclodextrin.

Author information

1
Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., Timişoara 300041, Romania. codrutasoica@umft.ro.
2
Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., Timişoara 300041, Romania. camelia.oprean@umft.ro.
3
Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., Timişoara 300041, Romania. fborcan@yahoo.com.
4
Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., Timişoara 300041, Romania. cadehelean@umft.ro.
5
Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., Timişoara 300041, Romania. trandafirescu.cristina@umft.ro.
6
Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., Timişoara 300041, Romania. dorinacoricovac@umft.ro.
7
Faculty of Medicine, Victor Babeş University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., Timişoara 300041, Romania. zcrainiceanu@gmail.com.
8
Department of Clinical Laboratory and Sanitary Chemistry, "Vasile Goldis" University, 1 Feleacului Str., Arad 310396, Romania. anaionescuro@yahoo.com.

Abstract

Oleanolic and ursolic acids are natural triterpenic compounds with pentacyclic cholesterol-like structures which gives them very low water solubility, a significant disadvantage in terms of bioavailability. We previously reported the synthesis of inclusion complexes between these acids and cyclodextrins, as well as their in vivo evaluation on chemically induced skin cancer experimental models. In this study the synergistic activity of the acid mixture included inside hydroxypropyl-gamma-cyclodextrin (HPGCD) was monitored using in vitro tests and in vivo skin cancer models. The coefficient of drug interaction (CDI) was used to characterize the interactions as synergism, additivity or antagonism. Our results revealed an increased antitumor activity for the mixture of the two triterpenic acids, both single and in complex with cyclodextrin, thus proving their complementary biologic activities.

PMID:
24747649
PMCID:
PMC6271422
DOI:
10.3390/molecules19044924
[Indexed for MEDLINE]
Free PMC Article

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