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Bioorg Chem. 2014 Jun;54:31-7. doi: 10.1016/j.bioorg.2014.03.006. Epub 2014 Mar 29.

Synthesis, characterization, theoretical, anti-bacterial and molecular docking studies of quinoline based chalcones as a DNA gyrase inhibitor.

Author information

1
Institute of Chemistry, University of the Punjab, Lahore, Pakistan. Electronic address: imranchemist.ali@gmail.com.
2
Department of Chemistry, University of Sargodha, Sargodha, Pakistan.
3
Department of Chemistry, Quaid-e-Azam University, Islamabad, Pakistan.
4
Sheikh Zayed Medical College & Hospital, Rahim Yar Khan, Pakistan.
5
Institute of Chemistry, University of the Punjab, Lahore, Pakistan.

Abstract

A series of fourteen (A1-A14) new qunioline based chalcones were synthesized by condensing 2,7-dichloro-8-methyl-3-formyl quinoline with acetophenone and acetylthiophenes, and subsequently characterized by IR, NMR and Mass spectroscopy. All the compounds were screened for antibacterial activities and found potentially active antibacterial agents. Bioassay, theoretical and dockings studies with DNA gyrase (the enzyme required for super coiling of DNA of bacteria) results showed that the type and positions of the substituents seemed to be critical for their antibacterial activities. The bromo and chloro substituted chalcone displayed high anti-bacterial activity. The A4 and A6 showed high interaction with DNA gyrase, contributing high free binding energy (ΔG -8.18 and -8.88 kcal).

KEYWORDS:

Acetophenone; Anti-bacterial; Chalcone; DNA gyrase; Quinoline; Theoretical

PMID:
24747187
DOI:
10.1016/j.bioorg.2014.03.006
[Indexed for MEDLINE]

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