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J Control Release. 2014 Sep 28;190:531-41. doi: 10.1016/j.jconrel.2014.03.050. Epub 2014 Apr 18.

Cell-mediated delivery of nanoparticles: taking advantage of circulatory cells to target nanoparticles.

Author information

1
Department of Chemical Engineering, Center for Bioengineering, University of California, Santa Barbara 93106, USA.
2
Department of Chemical Engineering, Center for Bioengineering, University of California, Santa Barbara 93106, USA. Electronic address: samir@engineering.ucsb.edu.

Abstract

Cellular hitchhiking leverages the use of circulatory cells to enhance the biological outcome of nanoparticle drug delivery systems, which often suffer from poor circulation time and limited targeting. Cellular hitchhiking utilizes the natural abilities of circulatory cells to: (i) navigate the vasculature while avoiding immune system clearance, (ii) remain relatively inert until needed and (iii) perform specific functions, including nutrient delivery to tissues, clearance of pathogens, and immune system surveillance. A variety of synthetic nanoparticles attempt to mimic these functional attributes of circulatory cells for drug delivery purposes. By combining the advantages of circulatory cells and synthetic nanoparticles, many advanced drug delivery systems have been developed that adopt the concept of cellular hitchhiking. Here, we review the development and specific applications of cellular hitchhiking-based drug delivery systems.

KEYWORDS:

Blood; Cell-mediated drug delivery; Cellular hitchhiking; Nanomedicine; Nanoparticles; Nanotechnology

PMID:
24747161
PMCID:
PMC4142097
DOI:
10.1016/j.jconrel.2014.03.050
[Indexed for MEDLINE]
Free PMC Article
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