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Pediatr Infect Dis J. 2014 Sep;33(9):984-6. doi: 10.1097/INF.0000000000000370.

Procalcitonin use in a pediatric intensive care unit.

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From the *St. Christopher's Hospital for Children, Philadelphia, PA; †Drexel University College of Medicine, Philadelphia, PA; ‡Alfred I duPont Hospital for Children, Wilmington, DE; §NYU Langone Medical Center, New York, NY; and ¶NYU School of Medicine, New York, NY.


We evaluated whether procalcitonin (PCT) might aid diagnosing serious bacterial infections in a general pediatric intensive care unit population. Two-hundred and one patients accounted for 332 PCT samples. A PCT ≥1.45 ng/mL had a positive predictive value of 30%, a negative predictive value of 93% and a sensitivity of 72% and a specificity of 75%. These data suggest PCT can assist in identifying patients without serious bacterial infections and limit antimicrobial use.

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