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Eur J Surg Oncol. 2014 Jul;40(7):875-82. doi: 10.1016/j.ejso.2014.03.027. Epub 2014 Apr 3.

Impact of radical operative treatment on the quality of life in women with vulvar cancer--a retrospective study.

Author information

  • 1Department of Gynecology and Obstetrics, University Hospitals Schleswig-Holstein, Campus Kiel, Arnold-Heller Str. 3, House 24, 24105 Kiel, Germany.
  • 2Reference Center for Quality of Life, University Hospitals Schleswig-Holstein, Campus Kiel, Arnold-Heller Str. 3, House 18, 24105 Kiel, Germany.
  • 3Institute of Medical Informatics and Statistics, University Hospitals Schleswig-Holstein, Campus Kiel, Brunswiker Str. 10, 24105 Kiel, Germany.
  • 4Department of Gynecology and Obstetrics, University Hospitals Schleswig-Holstein, Campus Kiel, Arnold-Heller Str. 3, House 24, 24105 Kiel, Germany. Electronic address: ibrahim.alkatout@uksh.de.

Abstract

OBJECTIVES:

For patients undergoing vulva surgery the quality of life (QoL) is generally accepted as an important outcome parameter in addition to long-term survival, mortality and complication rates. Less radical operative treatment can reduce morbidity and thereby improve quality of life. This study focuses on outcome in terms of QoL in patients comparing wide local excision (WLE) with radical vulvectomy and waiver of lymphonodectomy (LNE) with inguinofemoral lymphonodectomy.

METHODS:

In a retrospective single-center study from 2000 to 2010, 199 patients underwent surgery for vulvar cancer. To assess QoL, the EORTC QLQ-C30 and a tumor-specific module questionnaire were sent to all patients in the follow-up period.

RESULTS:

Women who underwent WLE have a superior QoL with regard to global health status and physical, role, emotional and cognitive functioning than those who underwent radical vulvectomy. Less radical surgery also implies less fatigue, nausea/vomiting, pain, insomnia, appetite loss, diarrhea and financial difficulties. After radical vulvectomy 89% of patients have sexual complications.

CONCLUSION:

Radical operative treatment, such as radical vulvectomy, causes deterioration in the QoL of these patients. An individualized, less radical surgery must be the aim in the treatment of vulvar cancer.

KEYWORDS:

Disease free survival; EORTC QLQ-C30; Lymphonodectomy; Overall survival; Quality of life; Radical vulvectomy; Vulvar cancer

PMID:
24746935
DOI:
10.1016/j.ejso.2014.03.027
[PubMed - indexed for MEDLINE]
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