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J Nutr Biochem. 2014 Jul;25(7):702-9. doi: 10.1016/j.jnutbio.2014.02.010. Epub 2014 Mar 18.

Extract of okra lowers blood glucose and serum lipids in high-fat diet-induced obese C57BL/6 mice.

Author information

1
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
2
Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
3
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address: chuang.shutcm@gmail.com.

Abstract

Okra is an important tropical vegetable and source of dietary medicine. Here, we assayed the effects of an ethanol extract of okra (EO) and its major flavonoids isoquercitrin and quercetin 3-O-gentiobioside on metabolic disorders in high-fat diet-induced obese mouse. We found that treatment with EO, isoquercitrin and quercetin 3-O-gentiobioside reduced blood glucose and serum insulin levels and improved glucose tolerance in obese mice. Meanwhile, serum triglyceride levels and liver morphology in the mice were significantly ameliorated by EO and isoquercitrin treatment. Total cholesterol levels in isoquercitrin and quercetin 3-O-gentiobioside treated mice were also reduced. We also found that EO inhibited the expression of nuclear receptor transcription factor PPARγ, which is an important regulator of lipid and glucose homeostasis. Furthermore, we determined that EO and quercetin 3-O-gentiobioside have antioxidant activity in vitro. Our results indicate that okra may serve as a dietary therapy for hyperglycemia and hypertriglyceridemia.

KEYWORDS:

Diabetes; Hyperlipidemia; Insulin resistance; Okra

PMID:
24746837
DOI:
10.1016/j.jnutbio.2014.02.010
[Indexed for MEDLINE]

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