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Int J Pharm. 2014 Jul 1;468(1-2):158-64. doi: 10.1016/j.ijpharm.2014.04.038. Epub 2014 Apr 18.

Synthesis and in vitro localization study of curcumin-loaded SPIONs in a micro capillary for simulating a targeted drug delivery system.

Author information

1
Nanoformulation Research Lab, Faculty of Pharmacy, Hamdard University, New Delhi, India. Electronic address: md.anwar2008@gmail.com.
2
Department of Mechanical Engineering, IIT Kanpur, Uttar Pradesh, India.
3
Nanoformulation Research Lab, Faculty of Pharmacy, Hamdard University, New Delhi, India.
4
Department of Pharmaceutics, Utrecht Institute of Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99, Utrecht 3584 CG, The Netherlands.
5
Nanoformulation Research Lab, Faculty of Pharmacy, Hamdard University, New Delhi, India. Electronic address: farhanja_2000@yahoo.com.

Abstract

Nano-sized curcumin-loaded super-paramagnetic iron oxide nanoparticles (CUR-OA-SPIONs) were synthesized chemically by co-precipitation method using oleic acid as a stabilizer and Myrj 52 as a surfactant. The synthesized nanoparticles were characterized for their shape, size, surface morphology, electrokinetic potential, magnetic properties, crystalinity, chemical interactions and thermal transitions. The synthesized CUR-OA-SPIONs were spherical, mono-dispersed, physically stable and super-paramagnetic in nature. In vitro localization study and aggregation dynamics of CUR-OA-SPIONs were studied with a flow of blood inside a square glass capillary (500×500 μm(2) cross section) in the presence of an externally applied magnetic field (Ms=1200 mT). This research which is first of its kind showed the fluorescent imaging of CUR-OA-SPIONs with respect to time to understand the aggregation dynamics of magnetic nanoparticles in a micro capillary simulating the case of targeted drug delivery system. The size of the aggregation increases with respect to time (t=0(+)s to t=500 s), while no significant change in the size of the aggregate was observed after time t=500 s.

KEYWORDS:

Curcumin; Drug localization; Drug targeting; Imaging; SPIONs; Superparamagnetic iron oxide nanoparticles

PMID:
24746694
DOI:
10.1016/j.ijpharm.2014.04.038
[Indexed for MEDLINE]

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