Format

Send to

Choose Destination
See comment in PubMed Commons below
Arthroscopy. 2014 Jun;30(6):715-23. doi: 10.1016/j.arthro.2014.02.032. Epub 2014 Apr 18.

Follow-up of a new arthroscopic technique for implantation of matrix-encapsulated autologous chondrocytes in the knee.

Author information

1
Orthopedic Sports Medicine and Arthroscopy Division and Tissue Engineering, Cell Therapy, and Regenerative Medicine Unit, National Institute of Rehabilitation, Mexico City, Mexico; National Polytechnic Institute, Mexico City, Mexico. Electronic address: clementeibarra@yahoo.com.
2
Orthopedic Sports Medicine and Arthroscopy Division, National Institute of Rehabilitation, Mexico City, Mexico.
3
Mexico School of Veterinary Medicine, National Autonomous University of Mexico, Mexico City, Mexico.
4
Tissue Engineering, Cell Therapy, and Regenerative Medicine Unit, National Institute of Rehabilitation, Mexico City, Mexico.

Abstract

PURPOSE:

The purpose of this study was to evaluate the clinical and sequential imaging follow-up results at a mean of 36 months after an arthroscopic technique for implantation of matrix-encapsulated autologous chondrocytes for the treatment of articular cartilage lesions on the femoral condyles.

METHODS:

Ten patients underwent arthroscopic implantation of autologous chondrocytes seeded onto a bioabsorbable scaffold. The patients were evaluated clinically using a visual analog scale (VAS) for pain and International Knee Documentation Committee (IKDC), Lysholm, and Tegner scores. Magnetic resonance imaging (MRI) T2-mapping and magnetic resonance observation of cartilage repair tissue (MOCART) evaluations were also performed. Second-look arthroscopic evaluation using the International Cartilage Repair Society (ICRS) grading classification was performed at 12 months.

RESULTS:

Compared with their preoperative values, at 36 months mean values ± standard deviation for the VAS scale for pain were 6.0 ± 1.5 to 0.3 ± 0.4. Improvement in clinical scores between preoperative values and 36-month follow-up values in subjective IKDC scores was 46.9 ± 18.5 to 77.2 ± 12.8; in Lysholm scores, it was 51.8 ± 25.1 to 87.9 ± 6.5, and in the Tegner activity scale it was 2.9 ± 1.7 to 5.9 ± 1.9. Mean T2 mapping and MOCART scores improved over time to 38.1 ± 4.4 ms and 72.5 ± 10, respectively. Mean ICRS score by second-look arthroscopy at 1 year was 10.4 ± 0.1.

CONCLUSIONS:

All clinical scores improved over time compared with the preoperative values. Clinical results are comparable with MRI T2 mapping and ICRS evaluations, suggesting that this arthroscopic technique for cell-based cartilage repair is efficacious and reproducible at a mean of 36 months of follow-up.

LEVEL OF EVIDENCE:

Level IV, therapeutic case series.

PMID:
24746406
DOI:
10.1016/j.arthro.2014.02.032
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center