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Immunol Allergy Clin North Am. 2014 May;34(2):407-22. doi: 10.1016/j.iac.2014.02.001.

Neuropsychological features of adult mastocytosis.

Author information

1
INSERM UMR 1163, Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutical Implications, Paris, France; Paris Descartes - Sorbonne Paris Cité University, Imagine Institute, Paris, France; CNRS ERL 8254, Paris, France; Laboratory of Excellence GR-Ex, Paris, France; Service d'Hématologie clinique, Assistance Publique-Hôpitaux de Paris, Hôpital Necker, Paris, France.
2
INSERM UMR 1163, Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutical Implications, Paris, France; Paris Descartes - Sorbonne Paris Cité University, Imagine Institute, Paris, France; CNRS ERL 8254, Paris, France; Laboratory of Excellence GR-Ex, Paris, France; Service d'Hématologie clinique, Assistance Publique-Hôpitaux de Paris, Hôpital Necker, Paris, France; Service de médecine Interne, Hôpital Tenon, Assistance Publique-Hôpitaux de Paris, Université Pierre et Marie Curie, 4 rue de la chine, Paris 75020, France.
3
Laboratoire de "Physiopathologie des maladies Psychiatriques", Centre de Psychiatrie et Neurosciences, U894, INSERM, Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Service de Psychiatrie, Faculté de Médecine Paris Descartes, Centre Hospitalier Sainte-Anne, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
4
INSERM UMR 1163, Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutical Implications, Paris, France; Paris Descartes - Sorbonne Paris Cité University, Imagine Institute, Paris, France; CNRS ERL 8254, Paris, France; Laboratory of Excellence GR-Ex, Paris, France; Service d'Hématologie clinique, Assistance Publique-Hôpitaux de Paris, Hôpital Necker, Paris, France. Electronic address: ohermine@gmail.com.

Abstract

In approximately one-third of cases, patients with mastocytosis can display various disabling general and neuropsychological symptoms. General signs may have a major impact on quality of life. Neurologic symptoms are less frequent. In a majority of cases, the pathophysiology of these symptoms is not known but could be linked to tissular mast cell infiltration, mast cell mediator release, or both. Treatments aiming at reducing mast cell number and/or stabilizating mast cells may be useful. Preliminary results suggest that treatment with kinase inhibitors may improve symptoms of depression and cognitive impairment.

KEYWORDS:

Anxiety; Cognitive impairment; Depression; Headache; Kit; Mast cell; Mastocytosis

PMID:
24745683
DOI:
10.1016/j.iac.2014.02.001
[Indexed for MEDLINE]

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