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Cancer Invest. 2014 Jul;32(6):226-35. doi: 10.3109/07357907.2014.905587. Epub 2014 Apr 18.

Apoptosis-inducing effects of Melissa officinalis L. essential oil in glioblastoma multiforme cells.

Author information

1
Laboratório de Imunologia Celular, Instituto de Biofísica Carlos Chagas Filho, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Cidade Universitária, Rio de Janeiro, RJ, Brazil,1.

Abstract

Current therapies for glioblastoma multiforme (GBM) are not effective. This study investigated the activity of the M. officinalis essential oil (EO) and its major component (citral) in GBM cell lines. Both EO and citral decreased the viability and induced apoptosis of GBM cells as demonstrated by DNA fragmentation and caspase-3 activation. Antioxidant prevented citral-induced death, indicating its dependence on the production of reactive oxygen species. Citral downmodulated the activity and inhibited the expression of multidrug resistance associated protein 1 (MRP1). These results show that EO, through its major component, citral, may be of potential interest for the treatment of GBM.

KEYWORDS:

Chemotherapy; Citral; Gliobastoma multiforme; Melissa officinali essential oil

PMID:
24745610
DOI:
10.3109/07357907.2014.905587
[Indexed for MEDLINE]

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