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J Appl Physiol (1985). 2014 Jun 15;116(12):1593-604. doi: 10.1152/japplphysiol.01174.2013. Epub 2014 Apr 17.

The effect of spaceflight on mouse olfactory bulb volume, neurogenesis, and cell death indicates the protective effect of novel environment.

Author information

1
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas;
2
Department of Basic Sciences, Division of Radiation Research, Loma Linda University and Medical Center, Loma Linda, California;
3
Department of Mechanical Engineering, University of Colorado at Boulder, Boulder, Colorado; and.
4
Department of Biomedical Engineering, University of North Carolina, Chapel Hill, North Carolina.
5
BioServe Space Technologies, Aerospace Engineering Sciences, University of Colorado at Boulder, Boulder, Colorado;
6
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas; amelia.eisch@utsouthwestern.edu.

Abstract

Space missions necessitate physiological and psychological adaptations to environmental factors not present on Earth, some of which present significant risks for the central nervous system (CNS) of crewmembers. One CNS region of interest is the adult olfactory bulb (OB), as OB structure and function are sensitive to environmental- and experience-induced regulation. It is currently unknown how the OB is altered by spaceflight. In this study, we evaluated OB volume and neurogenesis in mice shortly after a 13-day flight on Space Shuttle Atlantis [Space Transport System (STS)-135] relative to two groups of control mice maintained on Earth. Mice housed on Earth in animal enclosure modules that mimicked the conditions onboard STS-135 (AEM-Ground mice) had greater OB volume relative to mice maintained in standard housing on Earth (Vivarium mice), particularly in the granule (GCL) and glomerular (GL) cell layers. AEM-Ground mice also had more OB neuroblasts and fewer apoptotic cells relative to Vivarium mice. However, the AEM-induced increase in OB volume and neurogenesis was not seen in STS-135 mice (AEM-Flight mice), suggesting that spaceflight may have negated the positive effects of the AEM. In fact, when OB volume of AEM-Flight mice was considered, there was a greater density of apoptotic cells relative to AEM-Ground mice. Our findings suggest that factors present during spaceflight have opposing effects on OB size and neurogenesis, and provide insight into potential strategies to preserve OB structure and function during future space missions.

KEYWORDS:

activated caspase-3; doublecortin; environmental enrichment; low Earth orbit; neuroblasts

PMID:
24744382
PMCID:
PMC4152162
DOI:
10.1152/japplphysiol.01174.2013
[Indexed for MEDLINE]
Free PMC Article

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