Format

Send to

Choose Destination
Acta Trop. 2014 Aug;136:14-8. doi: 10.1016/j.actatropica.2014.04.006. Epub 2014 Apr 15.

Anti-Trypanosoma cruzi activity of 10 medicinal plants used in northeast Mexico.

Author information

1
Universidad Autónoma de Nuevo León, UANL, Facultad de Ciencias Biológicas, Laboratorio de Patología Molecular, Ave. Universidad S/N, Cd. Universitaria, 66451 San Nicolás de los Garza, NL, Mexico.
2
Universidad Autónoma de Nuevo León, UANL, Facultad de Ciencias Biológicas, Laboratorio de Fitoquímica, Ave. Universidad S/N, Cd. Universitaria, 66451 San Nicolás de los Garza, NL, Mexico.
3
Universidad Autónoma de Nuevo León, UANL, Facultad de Ciencias Biológicas, Laboratorio de Patología Molecular, Ave. Universidad S/N, Cd. Universitaria, 66451 San Nicolás de los Garza, NL, Mexico. Electronic address: lucio.galavizsl@uanl.edu.mx.

Abstract

The aim of this study was to screen the trypanocidal activity of plants used in traditional Mexican medicine for the treatment of various diseases related to parasitic infections. Cultured Trypanosoma cruzi epimastigotes were incubated for 96h with different concentrations of methanolic extracts obtained from Artemisia mexicana, Castela texana, Cymbopogon citratus, Eryngium heterophyllum, Haematoxylum brasiletto, Lippia graveolens, Marrubium vulgare, Persea americana, Ruta chalepensis and Schinus molle. The inhibitory concentration (IC50) was determined for each extract via a colorimetric method. Among the evaluated species, the methanolic extracts of E. heterophyllum, H. brasiletto, M. vulgare and S. molle exhibited the highest trypanocidal activity, showing percentages of growth inhibition between 88 and 100% at a concentration of 150μg/ml. These medicinal plants may represent a valuable source of new bioactive compounds for the therapeutic treatment of trypanosomiasis.

KEYWORDS:

Chagas disease; Medicinal plants; Trypanocidal activity

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center