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BMC Endocr Disord. 2014 Apr 17;14:36. doi: 10.1186/1472-6823-14-36.

Ectopic insulin secreting neuroendocrine tumor of kidney with recurrent hypoglycemia: a diagnostic dilemma.

Author information

1
Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India. vivekapjyotsna@yahoo.com.

Abstract

BACKGROUND:

Hypoglycemia secondary to ectopic insulin secretion of non-pancreatic tumors is rare.

CASE PRESENTATION:

We describe a middle aged woman with recurrent hypoglycemia. On evaluation, she was detected to have hyperinsulinemic hypoglycemia and right sided renal mass lesion. 68Ga-Dotanoc and 99mTc-HYNICTOC scans confirmed the intrarenal mass to be of neuroendocrine origin. Right nephrectomy was done and it turned out to be an insulin secreting neuroendocrine tumour. Neuroendocrine nature of this tumour was further confirmed by ultra-structural examination. Her hypoglycemia did not recur after resection of this tumour.

CONCLUSION:

Few cases of ectopic insulin secretion have been reported though some are not proven convincingly. This case addresses all the issues raised in previous case reports and proves by clinical, laboratory, functional imaging and immunohistochemical analysis that ectopic origin of insulin by non-pancreatic tumors does occur. To our knowledge, this is the first reported case of ectopic insulinoma arising from the kidney.

PMID:
24741994
PMCID:
PMC4046058
DOI:
10.1186/1472-6823-14-36
[Indexed for MEDLINE]
Free PMC Article

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