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J Immunol Res. 2014;2014:953203. doi: 10.1155/2014/953203. Epub 2014 Feb 19.

The expression of Bcl-2 and BID in gastric cancer cells.

Author information

1
Second Department of General and Gastroenterological Surgery, Medical University of Bialystok, M. Sklodowskiej-Curie 24a Street, 15-276 Bialystok, Poland.
2
Department of General Pathomorphology, Medical University of Bialystok, M. Sklodowskiej-Curie 24a Street, 15-276 Bialystok, Poland.

Abstract

BACKGROUND:

Bcl-2 and BID play a major role in the process of apoptosis and their dysfunction underlies carcinogenesis. The study objective was to assess the expression of Bcl-2 and BID in gastric cancer cells in correlation with chosen clinicopathological parameters, presence of Helicobacter pylori infection, and patients' survival.

MATERIALS AND METHODS:

The study involved 88 patients operated on for gastric cancer. The expressions of Bcl-2 and BID were determined immunohistochemically.

RESULTS:

Positive Bcl-2 expression was found in 55.7% and, BID in 53.6% of patients. The Bcl-2 expression correlated with stage pT3 and T4 gastric cancer (P < 0.05), with the intestinal type according to Lauren (P < 0.001), ulcerated type according to Bormann's classification (P < 0.01), and with local lymph node metastases (P < 0.05).

CONCLUSION:

The Bcl-2 protein plays a key role in the process of gastric cancer formation and is associated with the growth of definite types of gastric cancer.

PMID:
24741635
PMCID:
PMC3987977
DOI:
10.1155/2014/953203
[Indexed for MEDLINE]
Free PMC Article

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