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Methods Find Exp Clin Pharmacol. 1989 Apr;11(4):273-5.

Iloprost-induced writhing in mice and its suppression by morphine.

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1
University of Ankara, Faculty of Medicine, Department of Pharmacology, Turkey.

Abstract

Intraperitoneally (i.p.) administered iloprost produced a writhing response indicating nociception. This effect induced by 4 micrograms/kg iloprost was dose dependently protected by morphine with an ED50 (95% confidence limits) value of 0.039 (0.0018-0.067) mg/kg. On the other hand, indomethacin had no effect on iloprost-induced writhing. Thus, this effect of iloprost seems to be relatively more sensitive than other irritants-induced responses on determining the analgesic potency of narcotic drugs.

PMID:
2474118
[Indexed for MEDLINE]
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