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Indian J Pharmacol. 2014 Mar-Apr;46(2):157-60. doi: 10.4103/0253-7613.129305.

Effects of delayed puerarin treatment in long-term neurological outcomes of focal ischemic stroke in rats.

Author information

1
Department of Brain Center, Jiangsu Province Hospital of Traditional Chinese Medicine, Nanjing, Jiangsu Province 210029, China ; Department of Internal Neurology, Jiangsu Province Hospital of Traditional Chinese Medicine, Nanjing, Jiangsu Province 210029, China.
2
Department of Neurology, The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province 210046, China.

Abstract

OBJECTIVE:

The present study aimed at investigate the therapeutic effects of delayed puerarin treatment in neurological outcomes after middle cerebral artery occlusion (MCAO) in rats.

MATERIALS AND METHODS:

Male Wistar rats were subjected to MCAO for 120 min followed by reperfusion for 14 days. Puerarin (0, 50, 100, 200 mg/kg, intra-peritoneally) was administered at 24 h after stroke onset and repeated daily for 14 days. Neurological deficits were evaluated at 1, 4, 7, 14 days after stroke. Brain infarct volume and peri-infarct context vessel density were examined at 14 days after stroke.

RESULTS:

Puerarin significantly improved neurological functions up to 14 days after stroke and decreased the infarct volume with doses of 50 mg/kg and 100 mg/kg compared with saline controls. Puerarin treatment also significantly increased peri-infarct context vessel density at 14 days after stroke.

CONCLUSIONS:

Delayed treatment of puerarin initiated at 24 h after stroke is beneficial with improved long-term neurological outcomes and reduced infarction volume in focal ischemic stroke in rats. Enhanced vascular remodeling by puerarin might at least partially contribute to its beneficial effects.

KEYWORDS:

Cerebrovascular remodeling; focal cerebral ischemia; long-term neurological outcomes; puerarin; rats

PMID:
24741185
PMCID:
PMC3987182
DOI:
10.4103/0253-7613.129305
[Indexed for MEDLINE]
Free PMC Article
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