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J Infect Dis. 2014 Oct 1;210(7):1012-8. doi: 10.1093/infdis/jiu223. Epub 2014 Apr 16.

Targeting Staphylococcus aureus α-toxin as a novel approach to reduce severity of recurrent skin and soft-tissue infections.

Author information

1
Department of Pediatrics Department of Microbiology.
2
Department of Microbiology.
3
Department of Health Studies, University of Chicago, Illinois.

Abstract

Staphyococcus aureus frequently causes recurrent skin and soft-tissue infection (SSTI). In the pediatric population, elevated serum antibody targeting S. aureus α-toxin is correlated with a reduced incidence of recurrent SSTI. Using a novel model of recurrent SSTI, we demonstrated that expression of α-toxin during primary infection increases the severity of recurrent disease. Antagonism of α-toxin by either a dominant-negative toxin mutant or a small molecule inhibitor of the toxin receptor ADAM10 during primary infection reduces reinfection abscess severity. Early neutralization of α-toxin activity during S. aureus SSTI therefore offers a new therapeutic strategy to mitigate primary and recurrent disease.

KEYWORDS:

Staphylococcus aureus; novel therapeutics; recurrent infection; skin and soft-tissue infection; α-toxin

PMID:
24740631
PMCID:
PMC4207862
DOI:
10.1093/infdis/jiu223
[Indexed for MEDLINE]
Free PMC Article

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