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Nature. 2014 Apr 17;508(7496):331-9. doi: 10.1038/nature13001.

The ensemble nature of allostery.

Author information

1
Department of Biology and T.C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, Maryland 21218, USA.

Abstract

Allostery is the process by which biological macromolecules (mostly proteins) transmit the effect of binding at one site to another, often distal, functional site, allowing for regulation of activity. Recent experimental observations demonstrating that allostery can be facilitated by dynamic and intrinsically disordered proteins have resulted in a new paradigm for understanding allosteric mechanisms, which focuses on the conformational ensemble and the statistical nature of the interactions responsible for the transmission of information. Analysis of allosteric ensembles reveals a rich spectrum of regulatory strategies, as well as a framework to unify the description of allosteric mechanisms from different systems.

PMID:
24740064
PMCID:
PMC4224315
DOI:
10.1038/nature13001
[Indexed for MEDLINE]
Free PMC Article

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